Phenotypes Associated with This Genotype

Genotype
MGI:5301629

• Allelic Composition: Gt(ROSA)26Sor^{tm2(CAG-Notch2*)Uzs}/Gt(ROSA)26Sor⁺; Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:179036 )

• T1 B cells do not proceed to T2 B cell stage but directly develop into marginal zone B cells

decreased transitional stage T2 B cell number ( J:179036 )

• in the spleen

increased transitional stage T1 B cell number ( J:179036 )

• in the spleen

decreased mature B cell number ( J:179036 )

• in the bone marrow

decreased follicular B cell number ( J:179036 )

decreased pre-B cell number ( J:179036 )

• in the bone marrow

abnormal spleen marginal zone morphology ( J:179036 )

• enlarged

increased marginal zone B cell number ( J:179036 )

hematopoietic system

abnormal B cell differentiation ( J:179036 )

• T1 B cells do not proceed to T2 B cell stage but directly develop into marginal zone B cells

decreased transitional stage T2 B cell number ( J:179036 )

• in the spleen

increased transitional stage T1 B cell number ( J:179036 )

• in the spleen

decreased mature B cell number ( J:179036 )

• in the bone marrow

decreased follicular B cell number ( J:179036 )

decreased pre-B cell number ( J:179036 )

• in the bone marrow

abnormal spleen marginal zone morphology ( J:179036 )

• enlarged

increased marginal zone B cell number ( J:179036 )