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Phenotypes Associated with This Genotype
Genotype
MGI:5301627
Allelic
Composition		 Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129S6/SvEvTac * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (26 available)
Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
arrested B cell differentiation ( J:179036 )
• B cell development is blocked at pro-B cell stage
decreased B cell number ( J:179036 )
• in the spleen, inguinal lymph nodes, and peritoneal cavity

hematopoietic system
arrested B cell differentiation ( J:179036 )
• B cell development is blocked at pro-B cell stage
decreased B cell number ( J:179036 )
• in the spleen, inguinal lymph nodes, and peritoneal cavity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory