Phenotypes Associated with This Genotype

Genotype
MGI:5301527

• Allelic Composition: Esr1^tm3.1Ksk/Esr1^tm3.1Ksk
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Uterine abnormalities in Esr1^tm3.1Ksk/Esr1^tm3.1Ksk mice

reproductive system

decreased endometrial gland number ( J:176459 )

♀

absent corpus luteum ( J:176459 )

♀

abnormal ovarian follicle morphology ( J:176459 )

♀ • hemorrhagic

decreased primordial ovarian follicle number ( J:176459 )

♀

uterus cyst ( J:176459 )

♀ • with hemorrhagic follicles

small uterus ( J:176459 )

♀

uterus hypoplasia ( J:176459 )

♀

absent estrous cycle ( J:176459 )

♀

homeostasis/metabolism

increased circulating estradiol level ( J:176459 )

• 2-fold

increased luteinizing hormone level ( J:176459 )

• 4-fold

abnormal response/metabolism to endogenous compounds ( J:176459 )

• uterine tissue in ovariectomized mice fails exhibit uterotropic responses to estradiol treatment compared to in similarly treated wild-type mice

• however, uterine tissue in ovariectomized mice uterotropic responses to ICI182780 and tamoxifen

integument

abnormal mammary gland development ( J:176459 )

♀ • the mammary gland never develops beyond a rudimentary epithelial ductal tree unlike in wild-type mice

endocrine/exocrine glands

abnormal mammary gland development ( J:176459 )

♀ • the mammary gland never develops beyond a rudimentary epithelial ductal tree unlike in wild-type mice

decreased endometrial gland number ( J:176459 )

♀

absent corpus luteum ( J:176459 )

♀

abnormal ovarian follicle morphology ( J:176459 )

♀ • hemorrhagic

decreased primordial ovarian follicle number ( J:176459 )

♀

growth/size/body

uterus cyst ( J:176459 )

♀ • with hemorrhagic follicles