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Phenotypes Associated with This Genotype
Genotype
MGI:5301435
Allelic
Composition		 Oscartm1Ywc/Oscartm1Ywc
Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oscartm1Ywc mutation (1 available); any Oscar mutation (25 available)
Tyrobptm1Ttk mutation (2 available); any Tyrobp mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:178250 )
N
• mice exhibit normal osteoblast parameters
abnormal osteoclast morphology ( J:178250 )
• mice exhibit decreased osteoclast number and size compared with Tyrobptm1Ttk homozygotes
abnormal osteoclast differentiation ( J:178250 )
• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated cells from Tyrobptm1Ttk homozygotes
decreased osteoclast cell number ( J:178250 )
• compared with Tyrobptm1Ttk homozygotes
abnormal osteoclast physiology ( J:178250 )
• mice exhibit a reduction in eroded bone surface compared with Tyrobptm1Ttk homozygotes
abnormal trabecular bone morphology ( J:178250 )
• mice exhibit increased bone trabecula number, increased trabecular bone volume, and decreased trabecular space compared with Tyrobptm1Ttk homozygotes
increased trabecular bone volume ( J:178250 )
• compared with Tyrobptm1Ttk homozygotes
increased bone trabecula number ( J:178250 )
• compared with Tyrobptm1Ttk homozygotes

cellular
abnormal osteoclast differentiation ( J:178250 )
• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated cells from Tyrobptm1Ttk homozygotes

hematopoietic system
abnormal osteoclast morphology ( J:178250 )
• mice exhibit decreased osteoclast number and size compared with Tyrobptm1Ttk homozygotes
abnormal osteoclast differentiation ( J:178250 )
• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated cells from Tyrobptm1Ttk homozygotes
decreased osteoclast cell number ( J:178250 )
• compared with Tyrobptm1Ttk homozygotes
abnormal osteoclast physiology ( J:178250 )
• mice exhibit a reduction in eroded bone surface compared with Tyrobptm1Ttk homozygotes

immune system
abnormal osteoclast morphology ( J:178250 )
• mice exhibit decreased osteoclast number and size compared with Tyrobptm1Ttk homozygotes
abnormal osteoclast differentiation ( J:178250 )
• TGFB1-treated bone marrow macrophage immobilized on a minimal hOSCAR-binding triple-helical peptide (OSCpep) fail to exhibit an increate in giant TRAP+ osteoclasts unlike similarly treated cells from Tyrobptm1Ttk homozygotes
decreased osteoclast cell number ( J:178250 )
• compared with Tyrobptm1Ttk homozygotes
abnormal osteoclast physiology ( J:178250 )
• mice exhibit a reduction in eroded bone surface compared with Tyrobptm1Ttk homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/07/2026
MGI 6.24 		The Jackson Laboratory