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Phenotypes Associated with This Genotype
Genotype
MGI:5301103
Allelic
Composition		 Fbn1Tsk/Fbn1+
Il4tm1Nnt/Il4tm1Nnt
Genetic
Background		 involves: C57BL/6 * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1Tsk mutation (2 available); any Fbn1 mutation (174 available)
Il4tm1Nnt mutation (1 available); any Il4 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-4 secretion ( J:57957 )
• no Il4 is produced by Th2 cells

integument
integument phenotype ( J:57957 )
N
• no skin fibrosis develops

respiratory system
emphysema ( J:57957 )
• emphysema develops as expected for heterozygous Fbn1Tsk

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory