About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5301103
Allelic
Composition		 Fbn1Tsk/Fbn1+
Il4tm1Nnt/Il4tm1Nnt
Genetic
Background		 involves: C57BL/6 * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1Tsk mutation (2 available); any Fbn1 mutation (173 available)
Il4tm1Nnt mutation (1 available); any Il4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-4 secretion ( J:57957 )
• no Il4 is produced by Th2 cells

integument
integument phenotype ( J:57957 )
N
• no skin fibrosis develops

respiratory system
emphysema ( J:57957 )
• emphysema develops as expected for heterozygous Fbn1Tsk

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory