Phenotypes Associated with This Genotype

Genotype
MGI:5300502

• Allelic Composition: Skor2^{Tn(sb-Tyr)1799B.CA7BOve}/Skor2^{Tn(sb-Tyr)1799B.CA7BOve}
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:178891 )

• most mice die between 24 and 48 hours of birth due to failure to nurse, defective neuromuscular junction function, and/or respiratory failure

nervous system

decreased cerebellar granule cell precursor proliferation ( J:178891 )

• reduced proliferation

abnormal cerebellum morphology ( J:178891 )

abnormal Purkinje cell differentiation ( J:178891 )

abnormal cerebellum development ( J:178891 )

behavior/neurological

abnormal food intake ( J:178891 )

• neonates fail to nurse

ataxia ( J:178891 )

• unstable gait or ataxia in surviving mice

abnormal gait ( J:178891 )

• unstable gait or ataxia in surviving mice

cellular

abnormal Purkinje cell differentiation ( J:178891 )

decreased cerebellar granule cell precursor proliferation ( J:178891 )

• reduced proliferation

craniofacial

cleft secondary palate ( J:178891 )

• in most mice

growth/size/body

cleft secondary palate ( J:178891 )

• in most mice

decreased body size ( J:178891 )

• in surviving mice

respiratory system

respiratory failure ( J:178891 )

digestive/alimentary system

cleft secondary palate ( J:178891 )

• in most mice