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Phenotypes Associated with This Genotype
Genotype
MGI:5299187
Allelic
Composition		 Tln1tm1.1Bpet/Tln1tm4.1Crit
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pf4-icre)Q3Rsko mutation (1 available)
Tln1tm1.1Bpet mutation (0 available); any Tln1 mutation (145 available)
Tln1tm4.1Crit mutation (2 available); any Tln1 mutation (145 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal platelet physiology ( J:177971 )
• fibrogen binding is reduced compared to wild-type cells
• platelets exhibit defective agonist induced platelet integrin activation compared with wild-type mice
• however, binding in the presence of manganese is normal
reduced thrombolysis ( J:177971 )
• clot retraction is impaired compared to in wild-type mice
• however, clot retraction in the presence of manganese is normal

hematopoietic system
abnormal platelet physiology ( J:177971 )
• fibrogen binding is reduced compared to wild-type cells
• platelets exhibit defective agonist induced platelet integrin activation compared with wild-type mice
• however, binding in the presence of manganese is normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory