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Phenotypes Associated with This Genotype
Genotype
MGI:5298859
Allelic
Composition
Apoetm1Bres/Apoetm1Bres
Cd59atm1Bpm/Cd59atm1Bpm
Genetic
Background
involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Bres mutation (9 available); any Apoe mutation (163 available)
Cd59atm1Bpm mutation (0 available); any Cd59a mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice fed a high-fat diet exhibit increased atherosclerotic plaque formation, decreased deposition of membrane attack complex, increased smooth muscle cells in early plaques, and decreased smooth muscle cells in advanced plaques compared with Apoetm1Bres homozygotes
• in advanced plaques of mice fed a high-fat diet
• in early plaques of mice fed a high-fat diet

muscle
• in advanced plaques of mice fed a high-fat diet
• in early plaques of mice fed a high-fat diet


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory