Phenotypes Associated with This Genotype

Genotype
MGI:5298856

• Allelic Composition: Cd55^tm1Song/Cd55^tm1Song; Cd59a^tm1Bpm/Cd59a^tm1Bpm
• Genetic Background: B6.129-Cd55^tm1Song Cd59a^tm1Bpm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:113567 )

• following induction of experimental autoimmune myasthenia gravis

immune system

abnormal complement pathway ( J:113567 )

• following induction of experimental autoimmune myasthenia gravis, mice accumulate C3 in endplates unlike wild-type mice

increased susceptibility to experimental autoimmune myasthenia gravis ( J:113567 )

• following induction of experimental autoimmune myasthenia gravis, mice exhibit increased weight loss, decreased grip strength, loss of endplate structures, C3 deposits in endplates, increased muscle inflammation, and worse clinical scores requiring euthanasia compared with wild-type mice

• however, treatment with anti-C5 antibodies improves resistance and reduces endplate loss and muscle inflammation

myositis ( J:113567 )

• following induction of experimental autoimmune myasthenia gravis

behavior/neurological

decreased grip strength ( J:113567 )

• following induction of experimental autoimmune myasthenia gravis

muscle

myositis ( J:113567 )

• following induction of experimental autoimmune myasthenia gravis

abnormal muscle morphology ( J:113567 )

• following induction of experimental autoimmune myasthenia gravis, mice exhibit loss of endplate structures compared with wild-type mice

• however, treatment with anti-C5 antibodies reduces endplate structures loss

growth/size/body

weight loss ( J:113567 )

• following induction of experimental autoimmune myasthenia gravis that necessitated euthanasia