Phenotypes Associated with This Genotype

Genotype
MGI:5298852

• Allelic Composition: Cd59a^tm1Bpm/Cd59a^tm1Bpm
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased macrophage cell number ( J:148367 )

• 1 day post-injury the number of endoneurial macrophages is increased compared to in wild-type mice

abnormal complement pathway ( J:148367 )

• following nerve crush injury, mice exhibit increased C9/membrane attack complex accumulation compared with wild-type mice

increased susceptibility to induced arthritis ( J:146711 )

nervous system

abnormal Wallerian degeneration ( J:148367 )

• exacerbated following nerve crush injury

skeleton

increased susceptibility to induced arthritis ( J:146711 )

hematopoietic system

increased macrophage cell number ( J:148367 )

• 1 day post-injury the number of endoneurial macrophages is increased compared to in wild-type mice

homeostasis/metabolism

abnormal Wallerian degeneration ( J:148367 )

• exacerbated following nerve crush injury

increased susceptibility to injury ( J:148367 )

• following nerve crush injury, mice exhibit increased C9/membrane attack complex accumulation, exacerbated Wallerian degeneration, and increased macrophage accumulation compared with wild-type mice