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Phenotypes Associated with This Genotype
Genotype
MGI:5298851
Allelic
Composition		 Cd59atm1Bpm/Cd59atm1Bpm
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd59atm1Bpm mutation (0 available); any Cd59a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to experimental autoimmune encephalomyelitis ( J:89014 )
• mice treated with MOG33-35 exhibit earlier onset and more severe experimental autoimmune encephalomyelitis with increased demyelination and axon injury compared with wild-type mice

nervous system
demyelination ( J:89014 )
• in MOG33-35 treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory