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Phenotypes Associated with This Genotype
Genotype
MGI:5298403
Allelic
Composition
Cd274tm1Lpc/Cd274tm1Lpc
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274tm1Lpc mutation (0 available); any Cd274 mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following primary, but not secondary, Salmonella infection

immune system
• of CD8+ T cells in mice infected with rabies virus
• 10 days post-infection with rabies virus, mice exhibit increased migratory CD3+ T cell and CD8+ T cells into the nervous system compared with wild-type mice
• impaired after primary Salmonella infection
• after primary Salmonella infection
• increased IFN-gamma T cells following induction of experimental autoimmune encephalomyelitis
• mice treated with pIpC and immunized with ovalbumin exhibit a 2-fold increase in ovalbumin antigen-specific and ovalbumin-reactive CD8 T cells compared with wild-type mice
• slightly 5 weeks after primary Salmonella infection
• 5 weeks after primary Salmonella infection
• dendritic cells from mice treated with pIpC and immunized with ovalbumin induce 2- to 3-fold more ovalbumin-specific (Tet+) CD8 T cells compared with wild-type cells
• pIpC-stimulated bone marrow-derived dendritic cells induce a 3-fold increase in ovalbumin-specific CD8 T cells compared with wild-type cells
• pIpC-activated ovalbumin-pulsed dendritic cells suppress tumor growth more than wild-type mice
• following primary Salmonella infection, mice exhibit increased lethality, bacterial colonization of the liver after 5 weeks, and IgG2c and IgG1 response after 5 weeks and impaired Th1 cells development and reduced multifunctional Th1 cells compared with wild-type mice
• however, mice exhibit normal response to secondary infection and clonal expansion of Salmonella-specific CD4 T cells
• following primary, but not secondary, Salmonella infection
• mice infected with rabies virus exhibit reduced clinical signs of encephalitis, improved survival, increased CD8+ and CD3+ T cell migration into the nervous system, and reduced CD8+ T cell apoptosis compared with wild-type mice

cellular
• of CD8+ T cells in mice infected with rabies virus

hematopoietic system
• of CD8+ T cells in mice infected with rabies virus
• 10 days post-infection with rabies virus, mice exhibit increased migratory CD3+ T cell and CD8+ T cells into the nervous system compared with wild-type mice
• impaired after primary Salmonella infection
• after primary Salmonella infection
• increased IFN-gamma T cells following induction of experimental autoimmune encephalomyelitis
• mice treated with pIpC and immunized with ovalbumin exhibit a 2-fold increase in ovalbumin antigen-specific and ovalbumin-reactive CD8 T cells compared with wild-type mice
• slightly 5 weeks after primary Salmonella infection
• 5 weeks after primary Salmonella infection


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory