mortality/aging
• following primary, but not secondary, Salmonella infection
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• in mice infected with rabies virus
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immune system
• of CD8+ T cells in mice infected with rabies virus
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• 10 days post-infection with rabies virus, mice exhibit increased migratory CD3+ T cell and CD8+ T cells into the nervous system compared with wild-type mice
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• impaired after primary Salmonella infection
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• after primary Salmonella infection
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• increased IFN-gamma T cells following induction of experimental autoimmune encephalomyelitis
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• mice treated with pIpC and immunized with ovalbumin exhibit a 2-fold increase in ovalbumin antigen-specific and ovalbumin-reactive CD8 T cells compared with wild-type mice
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• slightly 5 weeks after primary Salmonella infection
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• 5 weeks after primary Salmonella infection
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• dendritic cells from mice treated with pIpC and immunized with ovalbumin induce 2- to 3-fold more ovalbumin-specific (Tet+) CD8 T cells compared with wild-type cells
• pIpC-stimulated bone marrow-derived dendritic cells induce a 3-fold increase in ovalbumin-specific CD8 T cells compared with wild-type cells
• pIpC-activated ovalbumin-pulsed dendritic cells suppress tumor growth more than wild-type mice
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• with increased IFN-gamma T cells
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• following primary Salmonella infection, mice exhibit increased lethality, bacterial colonization of the liver after 5 weeks, and IgG2c and IgG1 response after 5 weeks and impaired Th1 cells development and reduced multifunctional Th1 cells compared with wild-type mice
• however, mice exhibit normal response to secondary infection and clonal expansion of Salmonella-specific CD4 T cells
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• following primary, but not secondary, Salmonella infection
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• mice infected with rabies virus exhibit reduced clinical signs of encephalitis, improved survival, increased CD8+ and CD3+ T cell migration into the nervous system, and reduced CD8+ T cell apoptosis compared with wild-type mice
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• in mice infected with rabies virus
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cellular
• of CD8+ T cells in mice infected with rabies virus
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hematopoietic system
• of CD8+ T cells in mice infected with rabies virus
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• 10 days post-infection with rabies virus, mice exhibit increased migratory CD3+ T cell and CD8+ T cells into the nervous system compared with wild-type mice
|
• impaired after primary Salmonella infection
|
• after primary Salmonella infection
|
• increased IFN-gamma T cells following induction of experimental autoimmune encephalomyelitis
|
• mice treated with pIpC and immunized with ovalbumin exhibit a 2-fold increase in ovalbumin antigen-specific and ovalbumin-reactive CD8 T cells compared with wild-type mice
|
• slightly 5 weeks after primary Salmonella infection
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• 5 weeks after primary Salmonella infection
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