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Phenotypes Associated with This Genotype
Genotype
MGI:5298094
Allelic
Composition
Tg(CAG-cat,-Dcn*)#Debi/0
Tg(Kera-cre)KC4.3Wwk/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• lamellar structure is disrupted, more severely in the posterior stroma
• relatively normal lamellae are separated by abnormal zones in which collagen fibrils are irregularly packed and embedded in an electron lucent substance
• collagen fibrillogenesis is altered, interfibril spacing is increased, and in electron lucent zones fibril diameters are reduced
• disruption of the lamellar structure is more severe in the posterior stroma
• the extent of stromal opacity varies from hardly visualized cloudiness to overt opacity
• generally develop by about 1 month of age with a slow progression of opacity afterward
• opacity is more severe in the central cornea

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital stromal corneal dystrophy DOID:0060445 OMIM:610048
J:177392


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory