Mouse Genome Informatics
cn
    Tg(CAG-cat,-Dcn*)#Debi/0
Tg(Kera-cre)KC4.3Wwk/0

involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• lamellar structure is disrupted, more severely in the posterior stroma
• relatively normal lamellae are separated by abnormal zones in which collagen fibrils are irregularly packed and embedded in an electron lucent substance
• collagen fibrillogenesis is altered, interfibril spacing is increased, and in electron lucent zones fibril diameters are reduced
• disruption of the lamellar structure is more severe in the posterior stroma
• the extent of stromal opacity varies from hardly visualized cloudiness to overt opacity
• generally develop by about 1 month of age with a slow progression of opacity afterward
• opacity is more severe in the central cornea

Mouse Models of Human Disease
OMIM IDRef(s)
Corneal Dystrophy, Congenital Stromal; CSCD 610048 J:177392