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Phenotypes Associated with This Genotype
Genotype
MGI:5297840
Allelic
Composition		 Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (8 available); any Gt(ROSA)26Sor mutation (1062 available)
Nkx2-2tm2.1Suss mutation (0 available); any Nkx2-2 mutation (16 available)
Tg(Pdx1-cre/Esr1*)#Dam mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic beta cell differentiation ( J:177838 )
• mice treated with tamoxifen at 3 weeks of age exhibit beta cells to alpha cells reprogramming

cellular
abnormal pancreatic beta cell differentiation ( J:177838 )
• mice treated with tamoxifen at 3 weeks of age exhibit beta cells to alpha cells reprogramming

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory