Phenotypes Associated with This Genotype

Genotype
MGI:5297718

• Allelic Composition: Kit^W-v/Kit^W-v; Tg(Mt1-RET)304Ina/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased melanoma incidence ( J:88074 )

• 8 of 44 mutants develop slowly growing melanocytic tumors and two of these mutants die of melanoma at a late stage

decreased tumor incidence ( J:88074 )

• mutants exhibit suppression of melanoma development compared to single Tg(Mt1-RET)304Ina/0 mice, with only 13.7% of mice developing benign melanocytic tumors and none die by 12 months of age

• mutants are tumor free for up to 13.8 months compared to 3.7 months in single Tg(Mt1-RET)304Ina/0 mice

mortality/aging

premature death ( J:88074 )

• average lifespan of mutants is 15.8 +/- 5.9 months which is not significantly shorter than the mean life span of Kit^W-v homozygotes, but is shorter than wild-type controls

pigmentation

mosaic coat color ( J:88074 )

• mutants have a mosaic of white and black hairs/skin

abnormal melanogenesis ( J:88074 )

• mutants exhibit excess melanogenesis in and around hair bulbs in the area of black hairs/skin

integument

mosaic coat color ( J:88074 )

• mutants have a mosaic of white and black hairs/skin