Phenotypes Associated with This Genotype

Genotype
MGI:5297552

• Allelic Composition: Fstl1^tm1.1Mvdh/Fstl1^tm1.1Mvdh; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

pulmonary vascular congestion ( J:177416 )

• following pressure overload

decreased angiogenesis ( J:177416 )

• following pressure overload, the increase in myocardial capillary density is less than in wild-type mice

increased myocardial fiber size ( J:177416 )

• following pressure overload

abnormal coronary vessel morphology ( J:177416 )

• following pressure overload, the increase in myocardial capillary density is less than in wild-type mice

abnormal heart septum morphology ( J:177416 )

• increased thickness following pressure overload

increased heart weight ( J:177416 )

• following pressure overload

cardiac hypertrophy ( J:177416 )

• following pressure overload

increased heart left ventricle size ( J:177416 )

• increased left ventricular wall thickness following pressure overload

increased heart left ventricle weight ( J:177416 )

• following pressure overload

cardiac fibrosis ( J:177416 )

• following pressure overload

decreased heart left ventricle muscle contractility ( J:177416 )

• increased left ventricular dimension and reduced fractional shortening following pressure overload

increased response of heart to induced stress ( J:177416 )

• following pressure overload, mice exhibit exacerbated cardiac myocyte hypertrophy and dysfunction compared with similarly treated wild-type mice

homeostasis/metabolism

increased response of heart to induced stress ( J:177416 )

• following pressure overload, mice exhibit exacerbated cardiac myocyte hypertrophy and dysfunction compared with similarly treated wild-type mice

muscle

increased myocardial fiber size ( J:177416 )

• following pressure overload

decreased heart left ventricle muscle contractility ( J:177416 )

• increased left ventricular dimension and reduced fractional shortening following pressure overload

respiratory system

pulmonary vascular congestion ( J:177416 )

• following pressure overload

growth/size/body

increased heart weight ( J:177416 )

• following pressure overload

cardiac hypertrophy ( J:177416 )

• following pressure overload