Phenotypes Associated with This Genotype

Genotype
MGI:5297494

• Allelic Composition: Oxsr1^tm1.1Ssy/Oxsr1^tm1.1Ssy; Tg(Cdh16-cre)91Igr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine calcium level ( J:177443 )

increased urine potassium level ( J:177443 )

• increase in fractional excretion of potassium on both a normal chow and low potassium diet

increased urine sodium level ( J:177443 )

• elevated urine sodium excretion after 2 - 4 days on a low sodium diet compared to diet matched wild-type controls

decreased urine osmolality ( J:177443 )

• ambient osmolarity of spot urine is significantly reduced

abnormal kidney physiology ( J:177443 )

• blunted diuretic response to furosemide

homeostasis/metabolism

decreased circulating potassium level ( J:177443 )

• on both a normal chow and low potassium diet

increased urine calcium level ( J:177443 )

increased urine potassium level ( J:177443 )

• increase in fractional excretion of potassium on both a normal chow and low potassium diet

increased urine sodium level ( J:177443 )

• elevated urine sodium excretion after 2 - 4 days on a low sodium diet compared to diet matched wild-type controls

decreased urine osmolality ( J:177443 )

• ambient osmolarity of spot urine is significantly reduced

cardiovascular system

hypotension ( J:177443 )

• mice on a low sodium diet but not mice on a normal chow diet develop relative systolic hypotension

• however, on a normal chow diet blood pressure is normal