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Oxsr1tm1.1Ssy
Targeted Allele Detail
Summary
Symbol: Oxsr1tm1.1Ssy
Name: oxidative-stress responsive 1; targeted mutation 1.1, Sung-Sen Yang
MGI ID: MGI:5297491
Synonyms: OSR1flox
Gene: Oxsr1  Location: Chr9:119067498-119151493 bp, - strand  Genetic Position: Chr9, 71.33 cM
Alliance: Oxsr1tm1.1Ssy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177443
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 9 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 10 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:177443)
Generation of the Oxsr1tm1.1Ssy and Oxsr1tm1.2Ssy alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oxsr1 Mutation:  41 strains or lines available
References
Original:  J:177443 Lin SH, et al., Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17538-43
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory