Phenotypes for Bmal1 Syt10 MGI:5297485 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bmal1^tm1Bra/Bmal1^tm1Weit Syt10^{tm1.1(icre)Geno}/Syt10^{tm1.1(icre)Geno}
Genetic Background	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmal1^tm1Bra mutation (1 available); any Bmal1 mutation (137 available)
Bmal1^tm1Weit mutation (1 available); any Bmal1 mutation (137 available)
Syt10^{tm1.1(icre)Geno} mutation (0 available); any Syt10 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian behavior ( J:175596 )

• almost all animals display essentially no circadian rhythmicity (no clear circadian peak)

• under light-dark conditions (LD; 12:12 light/dark cycle), mutants are more active than wild-type in the light phase

• in animals, decreasing circadian amplitudes correlate with increasing ultradian amplitudes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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