Phenotypes for Fgf8 Six1 MGI:5297340 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fgf8^tm1.3Mrt/Fgf8⁺ Six1^tm1(cre)Xli/Six1⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8^tm1.3Mrt mutation (1 available); any Fgf8 mutation (18 available)
Six1^tm1(cre)Xli mutation (0 available); any Six1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Fgf8^tm1Moon/Fgf8⁺ Six1^tm1(cre)Xli/Six1⁺ newborns exhibit interrupted aortic arch-type B and vascular ring

cardiovascular system

cervical aortic arch ( J:172023 )

interrupted aortic arch ( J:172023 )

abnormal cardiac outflow tract development ( J:172023 )

• 83% display great vessel defects like cervical aortic arch or interrupted aortic arch type B

• embryos have severely hypoplastic proximal and distal outflow tract cushions compared to wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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