Phenotypes for Cd79a Sh3kbp1 MGI:5296787 MGI Mouse

immune system phenotype ( J:176805 )

N	• no gross development arrest in bone marrow

abnormal lymphocyte cell number ( J:176805 )

decreased B cell number ( J:176805 )

• recirculating B cells reduced about 20%

decreased immature B cell number ( J:176805 )

• reduced about 20%

• reduced about 20% in the spleen

• reduced about 20% in the spleen

decreased B-1a cell number ( J:176805 )

• peritoneal B-1a B cells are reduced about 8 fold

• reduced about 20% in the spleen

abnormal B cell physiology ( J:176805 )

• antigen specific B cells fail to increase due to T cell independent type II antibody response

• B cell proliferation after anti-IgM stimulation is severely reduced

abnormal humoral immune response ( J:176805 )

• T cell independent type II antibody responses are considerably reduced

abnormal lymphocyte cell number ( J:176805 )

decreased B cell number ( J:176805 )

• recirculating B cells reduced about 20%

decreased immature B cell number ( J:176805 )

• reduced about 20%

• reduced about 20% in the spleen

• reduced about 20% in the spleen

decreased B-1a cell number ( J:176805 )

• peritoneal B-1a B cells are reduced about 8 fold

• reduced about 20% in the spleen

abnormal B cell physiology ( J:176805 )

• antigen specific B cells fail to increase due to T cell independent type II antibody response

• B cell proliferation after anti-IgM stimulation is severely reduced

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24