Phenotypes Associated with This Genotype

Genotype
MGI:5296506

• Allelic Composition: Tyrobp^tm1Ttk/Tyrobp^tm1Ttk
• Genetic Background: B6.129P2-Tyrobp^tm1Ttk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:177613 )

• in response to with anti-BCR monoclonal antibody (anti-IgM mAb), LPS (a TLR-4 ligand), or CpG (a TLR-9 ligand) stimulation

increased germinal center B cell number ( J:177613 )

• increased frequencies following NP-CG or NP-Ficoll immunization

increased spleen germinal center number ( J:177613 )

• following NP-Ficoll immunization

increased spleen germinal center size ( J:177613 )

• following NP-CG immunization

increased IgG2a level ( J:177613 )

• following NP-CG immunization

increased IgG3 level ( J:177613 )

• following NP-Ficoll immunization

increased interleukin-6 secretion ( J:177613 )

• from B cells stimulated with CpG

increased autoantibody level ( J:177613 )

• against cardiolipin, double-strand DNA, and histone

increased anti-double stranded DNA antibody level ( J:177613 )

hematopoietic system

increased B cell proliferation ( J:177613 )

• in response to with anti-BCR monoclonal antibody (anti-IgM mAb), LPS (a TLR-4 ligand), or CpG (a TLR-9 ligand) stimulation

increased germinal center B cell number ( J:177613 )

• increased frequencies following NP-CG or NP-Ficoll immunization

increased spleen germinal center number ( J:177613 )

• following NP-Ficoll immunization

increased spleen germinal center size ( J:177613 )

• following NP-CG immunization

increased IgG2a level ( J:177613 )

• following NP-CG immunization

increased IgG3 level ( J:177613 )

• following NP-Ficoll immunization

cellular

increased B cell proliferation ( J:177613 )

• in response to with anti-BCR monoclonal antibody (anti-IgM mAb), LPS (a TLR-4 ligand), or CpG (a TLR-9 ligand) stimulation