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Phenotypes Associated with This Genotype
Genotype
MGI:5295469
Allelic
Composition		 Ptpn11tm1Ckq/Ptpn11+
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1Ckq mutation (0 available); any Ptpn11 mutation (44 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased lymphoblastic lymphoma incidence ( J:177285 )
• T cell lymphoblastic leukemia/lymphoma in 8 of 15 mice

mortality/aging

neoplasm
increased lymphoblastic lymphoma incidence ( J:177285 )
• T cell lymphoblastic leukemia/lymphoma in 8 of 15 mice
increased acute lymphoblastic leukemia incidence ( J:177285 )
• T cell lymphoblastic leukemia/lymphoma in 8 of 15 mice

immune system
immune system phenotype ( J:177285 )
N
• T and B cell development is normal
increased lymphoblastic lymphoma incidence ( J:177285 )
• T cell lymphoblastic leukemia/lymphoma in 8 of 15 mice

hematopoietic system
increased lymphoblastic lymphoma incidence ( J:177285 )
• T cell lymphoblastic leukemia/lymphoma in 8 of 15 mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory