Phenotypes Associated with This Genotype

Genotype
MGI:5295411

• Allelic Composition: Atad5^{Gt(RRF055)Byg}/Atad5⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Atad5^{Gt(RRF055)Byg}/Atad5⁺ mice are tumor-prone

mortality/aging

decreased tumor-free survival time ( J:176672 )

• all mice die between 11 and 20 months with spontaneous tumors or abscesses

neoplasm

increased tumor incidence ( J:176672 )

• 20 of 22 mice develop a wide spectrum of spontaneous tumors compared with 4 of 20 wild-type mice

increased gland tumor incidence ( J:176672 )

increased Harderian gland adenocarcinoma incidence ( J:176672 )

increased granulosa cell tumor incidence ( J:176672 )

♀ • granulosa cell tumor

increased liver adenocarcinoma incidence ( J:176672 )

increased lymphoma incidence ( J:176672 )

• in the lymph/lung/liver

increased T cell derived lymphoma incidence ( J:176672 )

increased lung carcinoma incidence ( J:176672 )

increased lung adenocarcinoma incidence ( J:176672 )

increased spindle cell carcinoma incidence ( J:176672 )

• in the small intestine/stomach

increased sarcoma incidence ( J:176672 )

• in the skeletal muscles, uterus, peripheral nerve, tail, and hindlimb

increased hemangiosarcoma incidence ( J:176672 )

endocrine/exocrine glands

increased gland tumor incidence ( J:176672 )

increased T cell derived lymphoma incidence ( J:176672 )

increased Harderian gland adenocarcinoma incidence ( J:176672 )

increased granulosa cell tumor incidence ( J:176672 )

♀ • granulosa cell tumor

liver/biliary system

increased liver adenocarcinoma incidence ( J:176672 )

cellular

aneuploidy ( J:176672 )

• in MMS-treated mouse embryonic fibroblasts

abnormal cell physiology ( J:176672 )

• gamma-irradiated mice exhibit a 3.3-fold increase in micronucleated reticulocytes compared with 1.4-fold in similarly treated wild-type mice

abnormal DNA repair ( J:176672 )

• in mouse embryonic fibroblasts treated with MMS

chromosomal instability ( J:176672 )

• MMS-treated mouse embryonic fibroblasts exhibit increased chromatid breaks compared with similarly treated wild-type cells

• gamma-irradiated mice exhibit a 3.3-fold increase in micronucleated reticulocytes compared with 1.4-fold in similarly treated wild-type mice indicating genomic stability

reproductive system

increased granulosa cell tumor incidence ( J:176672 )

♀ • granulosa cell tumor

respiratory system

increased lung carcinoma incidence ( J:176672 )

increased lung adenocarcinoma incidence ( J:176672 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:176672 )

reticulocytosis ( J:176672 )

• gamma-irradiated mice exhibit a 3.3-fold increase in micronucleated reticulocytes compared with 1.4-fold in similarly treated wild-type mice

homeostasis/metabolism

abnormal DNA repair ( J:176672 )

• in mouse embryonic fibroblasts treated with MMS

immune system

increased T cell derived lymphoma incidence ( J:176672 )