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Phenotypes Associated with This Genotype
Genotype
MGI:5295260
Allelic
Composition
Muc5actm1.1Evns/Muc5actm1.1Evns
Genetic
Background
B6.129S1-Muc5actm1.1Evns
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Muc5actm1.1Evns mutation (0 available); any Muc5ac mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in uninfected and T. muris-infected mice
• mice infected with T. muris fail to exhibit a reduction in worm burden at any time point unlike in similarly treated wild-type mice
• however, infected mice exhibit a normal TH2-type immune response

digestive/alimentary system
• increased numbers in T. muris-infected mice

homeostasis/metabolism
• in uninfected and T. muris-infected mice

vision/eye
• conjunctive mucous (goblet) cells are larger and show increased expression of Muc5b
• 11.4% of mice develop corneal opacification of varying severity and location; usually starts in one eye and progresses to the other
• mice show a decrease of tear film breakup time, and show corneal fluorescein staining unlike wild-type mice, indicating an unstable tear film
• however, tear volume is not changed, indicating a decline in tear quality but not in quantity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dry eye syndrome DOID:10140 J:195649


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory