Phenotypes Associated with This Genotype

Genotype
MGI:5295260

• Allelic Composition: Muc5ac^tm1.1Evns/Muc5ac^tm1.1Evns
• Genetic Background: B6.129S1-Muc5ac^tm1.1Evns

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased circulating interferon-gamma level ( J:177306 )

• in uninfected and T. muris-infected mice

increased susceptibility to parasitic infection ( J:177306 )

• mice infected with T. muris fail to exhibit a reduction in worm burden at any time point unlike in similarly treated wild-type mice

• however, infected mice exhibit a normal TH2-type immune response

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:177306 )

• increased numbers in T. muris-infected mice

homeostasis/metabolism

increased circulating interferon-gamma level ( J:177306 )

• in uninfected and T. muris-infected mice

vision/eye

abnormal conjunctiva goblet cell morphology ( J:195649 )

• conjunctive mucous (goblet) cells are larger and show increased expression of Muc5b

corneal opacity ( J:195649 )

• 11.4% of mice develop corneal opacification of varying severity and location; usually starts in one eye and progresses to the other

abnormal eye physiology ( J:195649 )

• mice show a decrease of tear film breakup time, and show corneal fluorescein staining unlike wild-type mice, indicating an unstable tear film

• however, tear volume is not changed, indicating a decline in tear quality but not in quantity

cellular

abnormal intestinal goblet cell morphology ( J:177306 )

• increased numbers in T. muris-infected mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dry eye syndrome		DOID:10140		J:195649