Phenotypes Associated with This Genotype

Genotype
MGI:5295055

• Allelic Composition: Grk2^tm1Gwd/Grk2^tm1Gwd; Cd79a^tm1(cre)Reth/Cd79a⁺
• Genetic Background: involves: 129 * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:176118 )

• in the lymph nodes

increased B cell number ( J:176118 )

• in the spleen and blood

increased follicular B cell number ( J:176118 )

increased marginal zone B cell number ( J:176118 )

increased CD4-positive, alpha-beta T cell number ( J:176118 )

• in the spleen

increased CD8-positive, alpha-beta T cell number ( J:176118 )

• in the spleen

abnormal B cell physiology ( J:176118 )

• B cells and marginal zone B cells exhibit increased chemotactic response to S1P compared with control cells

• long-term accumulation of B cells in the lymph node is reduced compared with control cells

• marginal zone B cells exhibit decreased chemotactic response to CCL21 compared with control cells

• marginal zone B cells exhibit increased chemotactic response to SEW2871 (S1PR1-selective agonist) compared with control cells

• marginal zone B cell relocalization to the follicle induced by FTY720 treatment is delayed compared to in control mice

• splenic follicular dendritic cells exhibit reduced deposition of phycoerythrin-induced complexes compared with control cells

• however, transfer into a S1P null mouse restores normal lymph node accumulation

hematopoietic system

decreased B cell number ( J:176118 )

• in the lymph nodes

increased B cell number ( J:176118 )

• in the spleen and blood

increased follicular B cell number ( J:176118 )

increased marginal zone B cell number ( J:176118 )

increased CD4-positive, alpha-beta T cell number ( J:176118 )

• in the spleen

increased CD8-positive, alpha-beta T cell number ( J:176118 )

• in the spleen

abnormal B cell physiology ( J:176118 )

• B cells and marginal zone B cells exhibit increased chemotactic response to S1P compared with control cells

• long-term accumulation of B cells in the lymph node is reduced compared with control cells

• marginal zone B cells exhibit decreased chemotactic response to CCL21 compared with control cells

• marginal zone B cells exhibit increased chemotactic response to SEW2871 (S1PR1-selective agonist) compared with control cells

• marginal zone B cell relocalization to the follicle induced by FTY720 treatment is delayed compared to in control mice

• splenic follicular dendritic cells exhibit reduced deposition of phycoerythrin-induced complexes compared with control cells

• however, transfer into a S1P null mouse restores normal lymph node accumulation