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Phenotypes Associated with This Genotype
Genotype
MGI:5294956
Allelic
Composition
Ctf1tm1Msd/Ctf1tm1Msd
Genetic
Background
B6.Cg-Ctf1tm1Msd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctf1tm1Msd mutation (1 available); any Ctf1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• weight gain is mostly due to increased adipose tissue (J:176727)
• weight gain is mostly due to increased adipose tissue (J:176727)
• mutants develop spontaneous adult-onset obesity, with weight gain first seen starting at 6 months of age (J:176727)
• mutants develop spontaneous adult-onset obesity, with weight gain first seen starting at 6 months of age (J:176727)
• 2 month old mutants fed a high-fat diet for 12 weeks gain more weight and accumulate more epididymal, retroperitoneal, and subcutaneous fat mass than wild-type mice (J:176727)
• 2 month old mutants fed a high-fat diet for 12 weeks gain more weight and accumulate more epididymal, retroperitoneal, and subcutaneous fat mass than wild-type mice (J:176727)

adipose tissue
• weight gain is mostly due to increased adipose tissue (J:176727)
• weight gain is mostly due to increased adipose tissue (J:176727)
• adipocyte hypertrophy is seen in mature mutants (J:176727)
• adipocyte hypertrophy is seen in mature mutants (J:176727)

behavior/neurological
• mutants become obese despite reduced food intake from 2-12 months compared to controls (J:176727)
• mutants become obese despite reduced food intake from 2-12 months compared to controls (J:176727)

homeostasis/metabolism
• hyperglycemia is seen from 6 months of age (J:176727)
• hyperglycemia is seen from 6 months of age (J:176727)
• hyperinsulinemia is seen from 6 months of age (J:176727)
• hyperinsulinemia is seen from 6 months of age (J:176727)
• increase in serum leptin levels in parallel with progression of weight gain (J:176727)
• increase in serum leptin levels in parallel with progression of weight gain (J:176727)
• hypercholesterolemia is seen from 6 months of age (J:176727)
• hypercholesterolemia is seen from 6 months of age (J:176727)
• old obese mutants exhibit lower circulating free fatty acids than controls (J:176727)
• old obese mutants exhibit lower circulating free fatty acids than controls (J:176727)
• in 2 month old mutants, energy expenditure is reduced compared to wild-type mice, with differences increasing with age (J:176727)
• in 2 month old mutants, energy expenditure is reduced compared to wild-type mice, with differences increasing with age (J:176727)
• 2 month old mutants fed a high-fat diet for 12 weeks gain more weight and accumulate more epididymal, retroperitoneal, and subcutaneous fat mass than wild-type mice (J:176727)
• 2 month old mutants fed a high-fat diet for 12 weeks gain more weight and accumulate more epididymal, retroperitoneal, and subcutaneous fat mass than wild-type mice (J:176727)
• in 2 month old mutants, oxygen consumption is reduced compared to wild-type mice, with differences increasing with age (J:176727)
• in 2 month old mutants, oxygen consumption is reduced compared to wild-type mice, with differences increasing with age (J:176727)
• respiratory quotient is elevated in mature obese mutants compared to mature wild-type mice (J:176727)
• respiratory quotient is elevated in mature obese mutants compared to mature wild-type mice (J:176727)
• insulin resistance is seen in obese mutants (J:176727)
• insulin resistance is seen in obese mutants (J:176727)
• adipocytes from obese mutants show increased baseline lipolysis and respond poorly to isoproterenol (J:176727)
• adipocytes from obese mutants show increased baseline lipolysis and respond poorly to isoproterenol (J:176727)

endocrine/exocrine glands
• pancreatic islet number is increased at 9 and 12 months of age (J:176727)
• pancreatic islet number is increased at 9 and 12 months of age (J:176727)
• pancreatic islet size is increased at 9 and 12 months of age (J:176727)
• pancreatic islet size is increased at 9 and 12 months of age (J:176727)

cellular
• mitochondrial DNA levels are reduced in white adipose tissue, indicating impaired mitochondrial biogenesis (J:176727)
• mitochondrial DNA levels are reduced in white adipose tissue, indicating impaired mitochondrial biogenesis (J:176727)
• oxygen consumption is reduced in adipocytes from obese mutants (J:176727)
• oxygen consumption is reduced in adipocytes from obese mutants (J:176727)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:176727


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory