Mouse Genome Informatics
hm
    Ctf1tm1Msd/Ctf1tm1Msd
B6.Cg-Ctf1tm1Msd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size/body
• weight gain is mostly due to increased adipose tissue
• mutants develop spontaneous adult-onset obesity, with weight gain first seen starting at 6 months of age
• 2 month old mutants fed a high-fat diet for 12 weeks gain more weight and accumulate more epididymal, retroperitoneal, and subcutaneous fat mass than wild-type mice

adipose tissue
• weight gain is mostly due to increased adipose tissue
• adipocyte hypertrophy is seen in mature mutants

behavior/neurological
• mutants become obese despite reduced food intake from 2-12 months compared to controls

homeostasis/metabolism
• hyperglycemia is seen from 6 months of age
• hyperinsulinemia is seen from 6 months of age
• increase in serum leptin levels in parallel with progression of weight gain
• hypercholesterolemia is seen from 6 months of age
• old obese mutants exhibit lower circulating free fatty acids than controls
• in 2 month old mutants, energy expenditure is reduced compared to wild-type mice, with differences increasing with age
• 2 month old mutants fed a high-fat diet for 12 weeks gain more weight and accumulate more epididymal, retroperitoneal, and subcutaneous fat mass than wild-type mice
• in 2 month old mutants, oxygen consumption is reduced compared to wild-type mice, with differences increasing with age
• respiratory quotient is elevated in mature obese mutants compared to mature wild-type mice
• insulin resistance is seen in obese mutants
• adipocytes from obese mutants show increased baseline lipolysis and respond poorly to isoproterenol

endocrine/exocrine glands
• pancreatic islet number is increased at 9 and 12 months of age
• pancreatic islet size is increased at 9 and 12 months of age

cellular
• mitochondrial DNA levels are reduced in white adipose tissue, indicating impaired mitochondrial biogenesis
• oxygen consumption is reduced in adipocytes from obese mutants

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:176727