Phenotypes Associated with This Genotype

Genotype
MGI:5294614

• Allelic Composition: Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased susceptibility to diet-induced obesity ( J:177113 )

• following doxycycline treatment mice gain less weight when fed a high fat diet compared to wild-type mice

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:177113 )

• following doxycycline treatment mice gain less weight when fed a high fat diet compared to wild-type mice

hypoglycemia ( J:177113 )

• following doxycycline treatment average fasting glucose is less than 50 mg/dL

improved glucose tolerance ( J:177113 )

• following doxycycline treatment on a normal or high fat diet

increased insulin sensitivity ( J:177113 )

• following doxycycline treatment