Phenotypes for Cdkn1c Tg(Mx1-cre)1Cgn MGI:5294433 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn1c^tm2.1Kei/Cdkn1c⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	B6.Cg-Cdkn1c^tm2.1Kei Tg(Mx1-cre)1Cgn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1c^tm2.1Kei mutation (1 available); any Cdkn1c mutation (19 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased hematopoietic stem cell number ( J:176209 )

• when Cdkn1c^tm2.1Kei is inherited maternally, mice exhibit decreased KSL fractions as early as 4 weeks after pIpC-treatment compared with control mice

abnormal hematopoietic stem cell physiology ( J:176209 )

• when Cdkn1c^tm2.1Kei is inherited maternally, hematopoietic stem cells from pIpC-treated mice exhibit decreased self-renewal capacity, decreased maintenance of quiescence, and increased frequency of apoptosis compared with control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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