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Phenotypes Associated with This Genotype
Genotype
MGI:5294359
Allelic
Composition
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+
Tg(Thy1-APP*)2.2Ingm/0
Genetic
Background
involves: C57BL/6 * DBA/1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APP*)2.2Ingm mutation (0 available)
Trib2Tg(Thy1-Trh/APP*)2.1Ingm mutation (0 available); any Trib2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
• neurodegeneration in the CA1 pyramidal cell layer
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

behavior/neurological
• delayed
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm
• display cramping or tremors when lifted by the tail
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

growth/size/body
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

hematopoietic system
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

immune system
• onset is later than in mice homozygous for Trib2Tg(Thy1-Trh/APP*)2.1Ingm

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:176575


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory