About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5294357
Allelic
Composition
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm
Genetic
Background
involves: C57BL/6 * DBA/1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trib2Tg(Thy1-Trh/APP*)2.1Ingm mutation (0 available); any Trib2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• between 5 and 7 months of age often due to feeding difficulties (J:176575)
• between 5 and 7 months of age often due to feeding difficulties (J:176575)

nervous system
• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age (J:176575)
• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age (J:176575)
• neuronal loss is seen at 3 months of age in the CA1 pyramidal cell layer (J:176575)
• loss of more than 40% of neurons in the rostral hippocampal CA1 region (J:176575)
• neuronal loss is seen at 3 months of age in the CA1 pyramidal cell layer (J:176575)
• loss of more than 40% of neurons in the rostral hippocampal CA1 region (J:176575)
• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age (J:176575)
• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age (J:176575)
• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age (J:176575)
• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age (J:176575)
• at 2 and 3 months of age (J:176575)
• reduced at 5 months of age (J:176575)
• at 2 and 3 months of age (J:176575)
• reduced at 5 months of age (J:176575)
• progressive age dependent astrocytosis beginning at 2 months of age (J:176575)
• progressive age dependent astrocytosis beginning at 2 months of age (J:176575)
• decreased fEPSP (J:176575)
• decreased fEPSP (J:176575)
• at 5 months of age (J:176575)
• at 5 months of age (J:176575)
• dramatic loss detectable at P28 (J:176575)
• dramatic loss detectable at P28 (J:176575)

behavior/neurological
• onset of behavioral phenotypes at 4 weeks of age (J:176575)
• onset of behavioral phenotypes at 4 weeks of age (J:176575)
• progressive decline in home cage free drinking behavior with age (J:176575)
• progressive decline in home cage free drinking behavior with age (J:176575)
• progressive decline in home cage free feeding behavior with age (J:176575)
• progressive decline in home cage free feeding behavior with age (J:176575)
• delayed (J:176575)
• delayed (J:176575)
• display cramping or tremors when lifted by the tail (J:176575)
• display cramping or tremors when lifted by the tail (J:176575)
• at 3 months of age (J:176575)
• at 3 months of age (J:176575)
• performance on a rotarod is less than 20% that of wild-type controls (J:176575)
• performance on a rotarod is less than 20% that of wild-type controls (J:176575)
• abnormal posture and rigor at 3 months of age (J:176575)
• abnormal posture and rigor at 3 months of age (J:176575)
• progressive decline with age (J:176575)
• progressive decline with age (J:176575)

growth/size/body
• about 30% lower compared to wild-type controls at 4.5 months of age (J:176575)
• about 30% lower compared to wild-type controls at 4.5 months of age (J:176575)
• detectable at 4 weeks of age (J:176575)
• detectable at 4 weeks of age (J:176575)

hematopoietic system
• at 2 and 3 months of age (J:176575)
• reduced at 5 months of age (J:176575)
• at 2 and 3 months of age (J:176575)
• reduced at 5 months of age (J:176575)

immune system
• at 2 and 3 months of age (J:176575)
• reduced at 5 months of age (J:176575)
• at 2 and 3 months of age (J:176575)
• reduced at 5 months of age (J:176575)

homeostasis/metabolism
• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age (J:176575)
• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age (J:176575)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:176575


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory