Phenotypes Associated with This Genotype

Genotype
MGI:5294357

• Allelic Composition: Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}/Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}
• Genetic Background: involves: C57BL/6 * DBA/1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:176575 )

• between 5 and 7 months of age often due to feeding difficulties

nervous system

amyloid beta deposits ( J:176575 )

• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age

abnormal hippocampus morphology ( J:176575 )

abnormal hippocampus CA1 region morphology ( J:176575 )

• neuronal loss is seen at 3 months of age in the CA1 pyramidal cell layer

• loss of more than 40% of neurons in the rostral hippocampal CA1 region

decreased hippocampus pyramidal cell number ( J:176575 )

• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age

hippocampus pyramidal cell degeneration ( J:176575 )

• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age

gliosis ( J:176575 )

microgliosis ( J:176575 )

• at 2 and 3 months of age

• reduced at 5 months of age

astrocytosis ( J:176575 )

• progressive age dependent astrocytosis beginning at 2 months of age

abnormal CNS synaptic transmission ( J:176575 )

abnormal excitatory postsynaptic potential ( J:176575 )

• decreased fEPSP

reduced long-term potentiation ( J:176575 )

• at 5 months of age

decreased prepulse inhibition ( J:176575 )

• dramatic loss detectable at P28

behavior/neurological

abnormal behavior ( J:176575 )

• onset of behavioral phenotypes at 4 weeks of age

decreased fluid intake ( J:176575 )

• progressive decline in home cage free drinking behavior with age

decreased food intake ( J:176575 )

• progressive decline in home cage free feeding behavior with age

impaired righting response ( J:176575 )

• delayed

limb grasping ( J:176575 )

• display cramping or tremors when lifted by the tail

tremors ( J:176575 )

• at 3 months of age

impaired coordination ( J:176575 )

• performance on a rotarod is less than 20% that of wild-type controls

abnormal posture ( J:176575 )

• abnormal posture and rigor at 3 months of age

decreased vertical activity ( J:176575 )

• progressive decline with age

growth/size/body

decreased body weight ( J:176575 )

• about 30% lower compared to wild-type controls at 4.5 months of age

slow postnatal weight gain ( J:176575 )

• detectable at 4 weeks of age

hematopoietic system

microgliosis ( J:176575 )

• at 2 and 3 months of age

• reduced at 5 months of age

immune system

microgliosis ( J:176575 )

• at 2 and 3 months of age

• reduced at 5 months of age

homeostasis/metabolism

amyloid beta deposits ( J:176575 )

• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:176575