Mouse Genome Informatics
hm
    Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm
involves: C57BL/6 * DBA/1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• between 5 and 7 months of age often due to feeding difficulties

nervous system
• neuronal loss is seen at 3 months of age in the CA1 pyramidal cell layer
• loss of more than 40% of neurons in the rostral hippocampal CA1 region
• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age
• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age
• at 2 and 3 months of age
• reduced at 5 months of age
• progressive age dependent astrocytosis beginning at 2 months of age
• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age
• at 5 months of age
• dramatic loss detectable at P28

behavior/neurological
• onset of behavioral phenotypes at 4 weeks of age
• progressive decline in home cage free drinking behavior with age
• progressive decline in home cage free feeding behavior with age
• display cramping or tremors when lifted by the tail
• at 3 months of age
• performance on a rotarod is less than 20% that of wild-type controls
• abnormal posture and rigor at 3 months of age
• progressive decline with age

growth/size
• about 30% lower compared to wild-type controls at 4.5 months of age
• detectable at 4 weeks of age

other phenotype
• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age

hematopoietic system
• at 2 and 3 months of age
• reduced at 5 months of age

immune system
• at 2 and 3 months of age
• reduced at 5 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:176575