Phenotypes Associated with This Genotype

Genotype
MGI:5292729

• Allelic Composition: Tg(TcraTcrb)1100Mjb/?
• Genetic Background: involves: C57BL/6 * MRL/Mp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:72817 )

• increased mortality after administration of OVA peptide 257-264

liver/biliary system

increased hepatocyte apoptosis ( J:72817 )

• extensive apoptosis develops after administration of OVA peptide 257-264

• extensive cell death

liver inflammation ( J:72817 )

• extensive infiltration of Valpha2⁺ CD8⁺ lymphocytes after administration of OVA peptide 257-264

• CD8⁺ lymphocytes spike 3 days after administration of OVA peptide 257-264

pale liver ( J:72817 )

• become pale and friable by the second day after administration of OVA peptide 257-264

immune system

liver inflammation ( J:72817 )

• extensive infiltration of Valpha2⁺ CD8⁺ lymphocytes after administration of OVA peptide 257-264

• CD8⁺ lymphocytes spike 3 days after administration of OVA peptide 257-264

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:72817 )

• increased mortality after administration of OVA peptide 257-264

cellular

increased hepatocyte apoptosis ( J:72817 )

• extensive apoptosis develops after administration of OVA peptide 257-264

• extensive cell death