Mouse Genome Informatics
hm
    Tfap2btm1Rbu/Tfap2btm1Rbu
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Postaxial accessory digits in Tfap2btm1Rbu/Tfap2btm1Rbu mice

mortality/aging
• most pups die within 24 h of birth

cardiovascular system
• progressive capillary congestion in newborns
• in all mice at 2 h and 6 h post birth

limbs/digits/tail
• an additional finger-like structure (with a single phalange and no nail) grows out laterally from the 5th finger on the forelimbs of all mice
• extra digits are seen on hindlimbs in only 5% of mice

respiratory system
• progressive capillary congestion in newborns
• disorganized and shrunken alveolar structure that is more severely affected in dying and dead pups

cellular
• in all mice at 2 h and 6 h post birth

Mouse Models of Human Disease
OMIM IDRef(s)
Char Syndrome 169100 J:175832