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Phenotypes Associated with This Genotype
Genotype
MGI:5292657
Allelic
Composition		 Irag1tm2.1Jens/Irag1tm2.1Jens
Taglntm2(PRKG1*)Hfm/Taglntm2(PRKG1*)Hfm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irag1tm2.1Jens mutation (0 available); any Irag1 mutation (49 available)
Taglntm2(PRKG1*)Hfm mutation (0 available); any Tagln mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
impaired muscle relaxation ( J:175887 )
• colon and vascular smooth muscle exhibit reduced cGMP-mediated relaxation compared with similarly treated wild-type smooth muscle

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory