Phenotypes Associated with This Genotype

Genotype
MGI:5292048

• Allelic Composition: Sgms2^tm1Kenw/Sgms2^tm1Kenw
• Genetic Background: B6.129S2-Sgms2^tm1Kenw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Sgms2^tm1Kenw/Sgms2^tm1Kenw mice on a high-fat diet are resistant to developing fatty liver

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:175924 )

• when fed a high-fat diet

abnormal circulating glucose level ( J:175924 )

• mice fed a high-fat diet do not exhibit an increase in fasting blood glucose unlike in similarly treated wild-type mice

increased circulating free fatty acids level ( J:175924 )

• when fed a high-fat diet

decreased circulating triglyceride level ( J:175924 )

• when fed a high-fat diet

improved glucose tolerance ( J:175924 )

• mice fed a high-fat diet exhibit improved glucose tolerance compared with similarly treated wild-type mice

increased insulin sensitivity ( J:175924 )

• mice fed a high-fat diet exhibit improved insulin sensitivity compared with similarly treated wild-type mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:175924 )

• when fed a high-fat diet

adipose tissue

decreased epididymal fat pad weight ( J:175924 )

• when fed a high-fat diet

cellular

abnormal cell physiology ( J:175924 )

• mouse embryonic fibroblasts (MEFs) exhibit impaired oleic acid compared with MEFs reconstituted with wild-type Sgms2

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:175924 )

• when fed a high-fat diet