Phenotypes Associated with This Genotype

Genotype
MGI:5291908

• Allelic Composition: Rbfox1^tm1.1Dblk/Rbfox1^tm1.1Dblk; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:176189 )

• in mice treated with kainic acid

reproductive system

reduced fertility ( J:176189 )

nervous system

nervous system phenotype ( J:176189 )

N • mice exhibit normal gross brain morphology

seizures ( J:176189 )

• infrequent spontaneous seizures

increased susceptibility to pharmacologically induced seizures ( J:176189 )

• increased incidence and duration of tonic-clonic seizures resulting in death in response to kainic acid treatment

tonic-clonic seizures ( J:176189 )

• in mice treated with kainic acid

decreased dendritic spine density ( J:176189 )

• very modest decrease in spine density in the dentate gyrus

abnormal excitatory postsynaptic potential ( J:176189 )

• mice require lower stimulus intensities to evoke field excitatory postsynaptic potentials compared with control mice

growth/size/body

decreased body size ( J:176189 )

• slightly

behavior/neurological

seizures ( J:176189 )

• infrequent spontaneous seizures

increased susceptibility to pharmacologically induced seizures ( J:176189 )

• increased incidence and duration of tonic-clonic seizures resulting in death in response to kainic acid treatment

tonic-clonic seizures ( J:176189 )

• in mice treated with kainic acid

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:176189 )

• in mice treated with kainic acid