Phenotypes Associated with This Genotype

Genotype
MGI:5289956

• Allelic Composition: Trp63^tm1Fmc/Trp63⁺; Trp73^tm1Fmc/Trp73⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:98958 )

• mutants survive for a shorter period of time than either single mutant, with some mutants dying by 6 months of age

premature aging ( J:98958 )

• 60% of mutants exhibit increased signs of aging, developing severe degenerative disc disease of the spine between 6 and 18 months of age

neoplasm

increased metastatic potential ( J:98958 )

• about 30% of mutants develop metastatic tumors

increased tumor incidence ( J:98958 )

• tumors undergo loss of heterozygosity

• 50% of mutant mice have multiple tumors of the same or distinct types

increased salivary gland adenoma incidence ( J:98958 )

• salivary adenoma

increased T cell derived lymphoma incidence ( J:98958 )

• mutants that die by 6 months of age develop thymic lymphoma, hemangiosarcoma, or myelogenous leukemia

increased lung adenoma incidence ( J:98958 )

increased chronic myelocytic leukemia incidence ( J:98958 )

• mutants that die by 6 months of age develop myelogenous leukemia, thymic lymphoma, or hemangiosarcoma

increased carcinoma incidence ( J:98958 )

• mice that die between 6 and 12 months of age most frequently develop carcinomas

increased mammary adenocarcinoma incidence ( J:98958 )

increased lung adenocarcinoma incidence ( J:98958 )

increased squamous cell carcinoma incidence ( J:98958 )

increased hemangiosarcoma incidence ( J:98958 )

• mutants that die by 6 months of age develop hemangiosarcoma, myelogenous leukemia, or thymic lymphoma

skeleton

intervertebral disk degeneration ( J:98958 )

• 60% of mutants develop severe degenerative disc disease of the spine between 6 and 18 months of age

• degenerative disc disease is consistent with spondylosis and is most frequent in the cervical and thoracic region

behavior/neurological

paralysis ( J:98958 )

• in 10% of mutants, degenerative disc disease is so severe, it results in partial paralysis

endocrine/exocrine glands

increased salivary gland adenoma incidence ( J:98958 )

• salivary adenoma

increased T cell derived lymphoma incidence ( J:98958 )

• mutants that die by 6 months of age develop thymic lymphoma, hemangiosarcoma, or myelogenous leukemia

increased mammary adenocarcinoma incidence ( J:98958 )

respiratory system

increased lung adenoma incidence ( J:98958 )

increased lung adenocarcinoma incidence ( J:98958 )

integument

increased mammary adenocarcinoma incidence ( J:98958 )

digestive/alimentary system

increased salivary gland adenoma incidence ( J:98958 )

• salivary adenoma

hematopoietic system

increased T cell derived lymphoma incidence ( J:98958 )

• mutants that die by 6 months of age develop thymic lymphoma, hemangiosarcoma, or myelogenous leukemia

immune system

increased T cell derived lymphoma incidence ( J:98958 )

• mutants that die by 6 months of age develop thymic lymphoma, hemangiosarcoma, or myelogenous leukemia

craniofacial

increased salivary gland adenoma incidence ( J:98958 )

• salivary adenoma

growth/size/body

increased salivary gland adenoma incidence ( J:98958 )

• salivary adenoma