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Phenotypes Associated with This Genotype
Genotype
MGI:5286072
Allelic
Composition
Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: 129T2/SvEms * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Bjw mutation (2 available); any Ptch1 mutation (23 available)
Tg(GFAP-cre)25Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by 4 weeks, mice become severely ill and must be sacrificed

nervous system
• expanded at E16.5
• thick and disorganized, at birth
• rhombic lip expansion at E16.5
• cerebellar cells exhibit increased neurospheres compared with wild-type mice

neoplasm

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:139573


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory