About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5286071
Allelic
Composition
Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background
involves: 129T2/SvEms * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Bjw mutation (2 available); any Ptch1 mutation (23 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by 10 weeks, mice start becoming severely ill and must be sacrificed
• all mice die by 29 weeks of age

nervous system
• granule neuron precursors in mice treated with tamoxifen at P4 exhibit increased proliferation unlike in wild-type mice
• in all mice treated with tamoxifen at E14.5 with a median age of tumor onset at 10 weeks
• in all mice treated with tamoxifen at P4 with a median age of tumor onset at 13 weeks
• in all mice treated with tamoxifen at P8 with a median age of tumor onset at 15.5 weeks
• in 29% of mice treated with tamoxifen at P10 with a median age of tumor onset at 19 weeks
• however, mice treated with tamoxifen at E10.5, at P12, or later than P12 do not develop tumors
• at P21 in mice treated with tamoxifen at P4
• cerebellar hyperplasia at 10 weeks of age

neoplasm
• in all mice treated with tamoxifen at E14.5 with a median age of tumor onset at 10 weeks
• in all mice treated with tamoxifen at P4 with a median age of tumor onset at 13 weeks
• in all mice treated with tamoxifen at P8 with a median age of tumor onset at 15.5 weeks
• in 29% of mice treated with tamoxifen at P10 with a median age of tumor onset at 19 weeks
• however, mice treated with tamoxifen at E10.5, at P12, or later than P12 do not develop tumors

cellular
• granule neuron precursors in mice treated with tamoxifen at P4 exhibit increased proliferation unlike in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:139573


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/13/2021
MGI 6.16
The Jackson Laboratory