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Phenotypes Associated with This Genotype
Genotype
MGI:5286070
Allelic
Composition
Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(Atoh1-cre)1Bfri/0
Genetic
Background
involves: 129T2/SvEms * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Bjw mutation (2 available); any Ptch1 mutation (23 available)
Tg(Atoh1-cre)1Bfri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by 4 weeks, mice start becoming severely ill and must be sacrificed
• all mice die 10 or 11 weeks of age

nervous system
N
• neuronal migration to form the laminar architecture and foliation in the cerebellum are normal
• granule neuron precursors exhibit persistent proliferation unlike in wild-type mice
• however, cells are still able to exit the cell cycle
• some regions exhibit nodular structure unlike the discrete layers of cells in wild-type mice
• thickened at P1 to P8 and at P21
• the external granule cell layer persists at P21 unlike in wild-type mice
• at P21 with cerebellar hyperplasia
• increased granule neuron precursors cells at P5

neoplasm

cellular
• granule neuron precursors exhibit persistent proliferation unlike in wild-type mice
• however, cells are still able to exit the cell cycle

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:139573


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory