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Phenotypes Associated with This Genotype
Genotype
MGI:5285910
Allelic
Composition		 Opn4tm1.1(cre)Saha/Opn4+
Pou4f2tm2.1Nat/Pou4f2+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm1.1(cre)Saha mutation (0 available); any Opn4 mutation (33 available)
Pou4f2tm2.1Nat mutation (1 available); any Pou4f2 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal suprachiasmatic nucleus morphology ( J:174940 )
• medial regions of the suprachiasmatic nucleus are not innervated at all
abnormal innervation ( J:174940 )
• the suprachiasmatic nucleus (SCN) is sparsely innervated by Pou4f2-positive ipRGCs (intrinsically photosensitive retinal ganglion cells)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory