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Phenotypes Associated with This Genotype
Genotype
MGI:5285873
Allelic
Composition
Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic
Background
B6NCrl.Cg-Cplx2tm1Rmnd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cplx2tm1Rmnd mutation (0 available); any Cplx2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• independent of parietal cortical neurotrauma, mice exhibit normal social interaction, sucrose preference test for anhedonia, forced alternation in a T-maze, novel object recognition, and pre-pulse inhibition
• in a Morris water maze, independent of parietal cortical neurotrauma
• in a Morris water maze, mice subjected to parietal cortical neurotrauma exhibit increased latency to escape by trial 6 through 8 compared with similarly treated wild-type mice
• independent of parietal cortical neurotrauma, mice spend less time in the center and intermediate area with increased time in the periphery of an open field compared with similarly treated wild-type mice
• however, mice exhibit normal anxiety-related behaviors in an elevated plus maze
• following parietal cortical neurotrauma
• in mice subjected to parietal cortical neurotrauma
• on a rotarod, independent of parietal cortical neurotrauma
• MK-801-treated mice subjected to parietal cortical neurotrauma exhibit increased hyperlocomotion compared with similarly treated wild-type mice
• in an open field, independent of parietal cortical neurotrauma

nervous system
• reduced volume following parietal cortical neurotrauma

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:175056


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory