Phenotypes for Espl1 Trp53 MGI:5285701 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Espl1^Gt(XL058)Byg/Espl1⁺ Trp53^tm1Tyj/Trp53⁺
Genetic Background	B6.129-Trp53^tm1Tyj Espl1^Gt(XL058)Byg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1^Gt(XL058)Byg mutation (1 available); any Espl1 mutation (92 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased carcinoma incidence ( J:174926 )

• about 50% of mice develop carcinomas over a period of 460 days which is an increased incidence compared to mice heterozygous for the Trp53 mutation alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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