Phenotypes Associated with This Genotype

Genotype
MGI:5285657

• Allelic Composition: Met^tm1Cpo/Met^tm1Sst; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal motor neuron innervation pattern ( J:174591 )

• mice exhibit reduced motor axon arborization (length and number of branches) in the pectoralis minor muscle compared with wild-type mice

• at P2, endplates in the pectoralis minor exhibit increased partially or completely denervated synapses compared with wild-type endplates

• however, mice exhibit normal innervation of the pectoralis minor muscle at E15.5 and of the pectoralis major

decreased motor neuron number ( J:174591 )

• by P2 in the C8 and T1 region of the spinal cord with no further reduction in adult mice

abnormal neuromuscular synapse morphology ( J:174591 )

• mice exhibit reduced motor axon arborization (length and number of branches) in the pectoralis minor muscle compared with wild-type mice

• at P2, endplates in the pectoralis minor exhibit increased partially or completely denervated synapses compared with wild-type endplates

• however, mice exhibit normal innervation of the pectoralis minor muscle at E15.5 and of the pectoralis major

behavior/neurological

impaired coordination ( J:174591 )

• in a wire hang test but not a rotarod