Phenotypes Associated with This Genotype

Genotype
MGI:5285614

• Allelic Composition: H2-Ab1^b-tm1Koni/H2-Ab1^b-tm1.1Koni; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:131774 )

N • T regulatory cells exhibit division in response to IL2

N • CD4+CD25+ exhibit effective suppressive activity

increased CD4-positive, alpha-beta T cell number ( J:131774 )

• 1.5- to 2-fold in CD4+CD8- but not CD8-CD4+CD25+

abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology ( J:131774 )

• CD4+CD25+ fopx3^high T regulatory cells exhibit reduced CD25 expression compared with control cells

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:131774 )

• 2-fold

abnormal T cell activation ( J:131774 )

• mice exhibit a reduced number of preactivated CD4 T cells and CD4+CD25+ cells compared with wild-type mice

decreased level of surface class II molecules ( J:131774 )

• in splenic hemopoietic cells (B cells, CD8a- dendritic cells, and CD8a+ dendritic cells) and Langerhans cells

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:131774 )

• 1.5- to 2-fold in CD4+CD8- but not CD8-CD4+CD25+

abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology ( J:131774 )

• CD4+CD25+ fopx3^high T regulatory cells exhibit reduced CD25 expression compared with control cells

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:131774 )

• 2-fold

abnormal T cell activation ( J:131774 )

• mice exhibit a reduced number of preactivated CD4 T cells and CD4+CD25+ cells compared with wild-type mice