Phenotypes for Sox4 Sox11 Sox12 MGI:5285380 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sox11^tm2.2Weg/Sox11⁺ Sox12^tm2.1Weg/Sox12^tm2.1Weg Sox4^tm1.1Vlf/Sox4⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm2.2Weg mutation (0 available); any Sox11 mutation (14 available)
Sox12^tm2.1Weg mutation (0 available); any Sox12 mutation (8 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

persistent truncus arteriosus ( J:175338 )

double outlet right ventricle ( J:175338 )

ventricular septal defect ( J:175338 )

• incomplete ventricular septation

skeleton

abnormal cranium morphology ( J:175338 )

• hypomineralized skull

abnormal sternebra morphology ( J:175338 )

• fusion and /or deletion

• split sternal bars in all mice

sternebra fusion ( J:175338 )

abnormal vertebrae morphology ( J:175338 )

• vertebral body duplication in all mice

abnormal bone mineralization ( J:175338 )

• hypomineralized skull

craniofacial

abnormal cranium morphology ( J:175338 )

• hypomineralized skull

immune system

small spleen ( J:175338 )

• in all mice

hematopoietic system

small spleen ( J:175338 )

• in all mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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