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Phenotypes Associated with This Genotype
Genotype
MGI:5285220
Allelic
Composition
Bsndtm1.1Suc/Bsndtm1.1Suc
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bsndtm1.1Suc mutation (0 available); any Bsnd mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice fed a normal diet exhibit normal urine and blood homeostasis
• when fed a low-salt diet
• mild when fed a low-salt diet
• when fed a low-salt diet
• when fed a low-salt diet
• mild when fed a low-salt diet
• mild metabolic alkalosis when fed a low-salt diet
• in vivo clearance of hydrochlorothiazide (HCT) is blunted compared to in wild-type mice
• however, clearance of furosemide is normal

renal/urinary system
• mild when fed a low-salt diet
• in vitro, the thin ascending limb of Henle's loop exhibits decreased steady-state and 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB)-sensitive chloride diffusion voltage compared to in wild-type tissue
• however, the thick ascending limb of Henle's loops exhibits normal steady-state and NPPB-sensitive chloride diffusion voltage
• mild when fed a low-salt diet

cardiovascular system
• when fed a low-salt diet

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Bartter disease type 4a DOID:0110145 OMIM:602522
J:175265


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory