Phenotypes Associated with This Genotype

Genotype
MGI:5142491

• Allelic Composition: Kitl^Sl-m/Kitl^Sl-m
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

anemia ( J:5009 , J:13416 )

• due to loss of blood through their gastrointestinal tracts (J:13416)

• blood sampled from the tail vein has a greatly decreased RBC count and greatly increased MCV (J:13416)

integument

abnormal coat/hair pigmentation ( J:13416 )

• slightly anemic

absent coat pigmentation ( J:13416 )

• mice are strikingly white with (normal) black eyes

pigmentation

abnormal coat/hair pigmentation ( J:13416 )

• slightly anemic

absent coat pigmentation ( J:13416 )

• mice are strikingly white with (normal) black eyes

reproductive system

reduced female fertility ( J:13137 , J:13416 )

♀ • notall females are fertile and no fertile female has had more than one litter (J:13137)

♀ (J:13416)

male infertility ( J:13416 )

♂

cardiovascular system

gastrointestinal hemorrhage ( J:5009 )

• mice lose approximately 3.5 per cent of their blood volume into their gastrointestinal tract daily

• study shows iron is lost but red blood cell loss was not demonstrated

digestive/alimentary system

gastrointestinal hemorrhage ( J:5009 )

• mice lose approximately 3.5 per cent of their blood volume into their gastrointestinal tract daily

• study shows iron is lost but red blood cell loss was not demonstrated

mortality/aging

premature death ( J:5009 , J:13416 )

• occasionally a mouse has survived up to a year (J:13416)