About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5141758
Allelic
Composition		 Sos1tm1.1Les/Sos1tm1.1Les
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sos1tm1.1Les mutation (0 available); any Sos1 mutation (69 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:174536 )
• a 25% reduction in proliferation of both DN4 and DP thymocytes
decreased thymocyte number ( J:174536 )
• 50% reduction in total thymocyte numbers
decreased DN4 thymocyte number ( J:174536 )
• decrease in the number and percentage of DN4 cells and an increase in the DN3:DN4 ratio
decreased double-negative T cell number ( J:174536 )
• while the total number is reduced the percentage of DN cells is increased
decreased CD4-positive, alpha-beta T cell number ( J:174536 )
• decrease in the number of CD4+ thymocytes
• however, the number of peripheral CD4+ lymph node T cells is not decreased
decreased CD8-positive, alpha-beta T cell number ( J:174536 )
• decrease in the number of CD8+ thymocytes
• however, the number of peripheral CD8+ lymph node T cells is not decreased

hematopoietic system
decreased T cell proliferation ( J:174536 )
• a 25% reduction in proliferation of both DN4 and DP thymocytes
decreased thymocyte number ( J:174536 )
• 50% reduction in total thymocyte numbers
decreased DN4 thymocyte number ( J:174536 )
• decrease in the number and percentage of DN4 cells and an increase in the DN3:DN4 ratio
decreased double-negative T cell number ( J:174536 )
• while the total number is reduced the percentage of DN cells is increased
decreased CD4-positive, alpha-beta T cell number ( J:174536 )
• decrease in the number of CD4+ thymocytes
• however, the number of peripheral CD4+ lymph node T cells is not decreased
decreased CD8-positive, alpha-beta T cell number ( J:174536 )
• decrease in the number of CD8+ thymocytes
• however, the number of peripheral CD8+ lymph node T cells is not decreased

endocrine/exocrine glands
decreased thymocyte number ( J:174536 )
• 50% reduction in total thymocyte numbers
decreased DN4 thymocyte number ( J:174536 )
• decrease in the number and percentage of DN4 cells and an increase in the DN3:DN4 ratio

cellular
decreased T cell proliferation ( J:174536 )
• a 25% reduction in proliferation of both DN4 and DP thymocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory