Mouse Genome Informatics
cn
    Ctnnb1tm1Mmt/Ctnnb1+
Fgfr3tm4Cxd/Fgfr3+
Tg(Upk2-cre)6Xrw/0

involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• shorter survival due to lung cancer, with a survival time between 200-400 days

renal/urinary system
• 100% of mutants exhibit areas of hyperproliferation in the bladder urothelium from about 3 months of age, however these lesions do not progress further when examined at 12 months of age

tumorigenesis
N
• despite hyperproliferation in the bladder, mutants do not develop urothelial carcinoma by 12 months of age (J:174242)
• mutants do not develop skin papillomas (J:174242)
• 36% of mutants develop lung tumors by 1 year of age
• lung tumors resemble solitary fibrous tumors of the lugs (hemangiopericytomas)

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:174242