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Phenotypes Associated with This Genotype
Genotype
MGI:5141741
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Fgfr3tm4Cxd/Fgfr3+
Tg(Upk2-cre)6Xrw/0
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (27 available)
Fgfr3tm4Cxd mutation (0 available); any Fgfr3 mutation (17 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• 36% of mutants develop lung tumors by 1 year of age
• lung tumors resemble solitary fibrous tumors of the lugs (hemangiopericytomas)

mortality/aging
• shorter survival due to lung cancer, with a survival time between 200-400 days

renal/urinary system
• 100% of mutants exhibit areas of hyperproliferation in the bladder urothelium from about 3 months of age, however these lesions do not progress further when examined at 12 months of age

neoplasm
N
• despite hyperproliferation in the bladder, mutants do not develop urothelial carcinoma by 12 months of age
• mutants do not develop skin papillomas
• lung tumors resemble solitary fibrous tumors of the lugs (hemangiopericytomas)
• 36% of mutants develop lung tumors by 1 year of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:174242


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory